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Human Peripheral Blood Converted Sensory Neurons

While previous reports demonstrated that human sensory neurons could be directly converted from primitive CD34+ hematopoietic cells, the small scale and derivation from less abundant allogenic sources of cord or drug mobilized peripheral blood represented problems. Now, a team led by Tony J. Collins and Mickie Bhatia (McMaster University, Hamilton, Ontario, Canada) report the development of a protocol for the generation of human sensory neurons directly converted from conventionally drawn adult peripheral blood. Vojnits et al. hope that their new platform will allow the study of peripheral nervous system‐related neuropathies and identify drugs that may prevent, block, or repair chemotherapy‐induced peripheral nerve damage. See STEM CELLS Translational Medicine for the fine print.