You are here

Functional APC Required for ESC Self-renewal

To study the role of Adenomatous polyposis coli (APC), a negative regulator of Wnt/β‐catenin signaling, in human embryonic stem cells (ESCs), researchers from the lab of Dalit Ben‐Yosef (Tel‐Aviv Sourasky Medical Center, Israel) directly targeted APC in hESCs carrying a germline APC mutation. Reporting in STEM CELLS, Preisler et al. now show active repression by the tumor suppressor APC keeps Wnt/ß‐catenin signaling activity low in undifferentiated hESCs. Interestingly, the team also discovered that APC has a pivotal role in hESC self‐renewal by inhibiting Wnt/ß‐catenin induced differentiation and that cells rapidly differentiate into mesendoderm upon APC loss.