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Endogenous Stem Cell Response After SCI

Emerging evidence suggests that many components of the secondary injury cascade following spinal cord injury (SCI), generally viewed as deleterious to host neuronal and glial cells, may trigger the activation of endogenous ependymal neural stem/progenitor cells (NSPCs). Now, researchers led by Charles H. Tator (University of Toronto, Canada) highlight new findings describing the response of endogenous NSPCs to spinal cord trauma, redefining the secondary mechanisms of spinal cord injury through the lens of the endogenous population of stem/progenitor cells. Moreover, Hachem et al. outline how these insights can fuel novel stem cell‐based therapeutic strategies to repair the injured spinal cord; see all the details in this new review article in STEM CELLS now!