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Cell Cycle Dynamics of Pluripotent Stem Cells

Recently, researchers from the labs of Anshul Kundaje and Sundari Chetty (Stanford University School of Medicine, California, USA) set out to understand the molecular properties of the cell cycle of human pluripotent stem cells (hPSCs) as a means to promote efficient differentiation. Reporting in STEM CELLS, Shcherbina et al. employed the Fluorescence Ubiquitin Cell Cycle Indicator system and RNA‐sequencing on cell cycle sorted hPSCs primed and unprimed for differentiation to reveal that gene expression patterns of signaling factors/developmental regulators alter in a cell cycle‐specific manner as cell transit towards differentiation and highlight an important role for PI3K signaling in regulating these transitory states.