You are hereAugust 14, 2019
β-Cell Mass Formation in Stem Cell-Derived Implants
A recent study from the lab of Daniel G. Pipeleers (Brussels Free University, Belgium) reported on ex vivo device‐encapsulated human embryonic stem cell‐derived pancreatic endoderm implants in mice that established a metabolically adequate functional β‐cell mass. Now, Robert et al. describe the optimization steps used to enhance this protocol in a STEM CELLS Translational Medicine study. The authors investigated the formation of a β‐cell mass inside the device to identify the underlying mechanisms and conditions that reduce variability and, in doing so, elucidated a protocol that resulted in the more consistent formation of a glucose‐controlling β‐cell mass.