You are hereJune 12, 2017
Study Shows Stem Cell Infusion Helps Treat Severe Cases of Aplastic Anemia
DURHAM, NC - A new study demonstrates how an infusion of stem cells can assist in treating severe cases of aplastic anemia (AA) that do not respond to immunosuppressive therapy (IST) alone. The study, which appears in STEM CELLS Translational Medicine (SCTM), offers hope for patients with this rare disease, which occurs when the bone marrow does not produce enough blood cells to meet the body’s needs.
People with AA suffer from fatigue, frequent infections, rapid heart rate and bleeding. The more severe cases can be life threatening. While IST is accepted as the first-line treatment option for AA, 30 to 40 percent of patients with severe cases don’t respond well to treatment and continue to suffer from an abnormally low level of red blood cells, white blood cells and platelets. IST therapy generally consists of anti-thymocyte globulin, which is an infusion of horse or rabbit-derived antibodies against human T cells, and the immunosuppressant medication cyclosporine.
These patients who don’t respond to IST might require an allogeneic hematopoietic stem cell transplant (HSCT). However, about a third of them aren’t able to find a suitable donor. Also, people aged 50 and older are not eligible for transplant. Another issue with HSCT is that complications such as graft versus host disease and graft failure may occur. As such, the five-year overall survival rate of patients with severe AA that is refractory to IST is less than 60 percent.
In the SCTM study, a team of researchers led by Yan Pang, M.D., and Yang Xiao, M.D., Ph.D., of the Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, in China, wanted to learn whether bone marrow-derived mesenchymal stromal cell (BM-MSC) transfusions might help patients who did not respond to IST. The phase two clinical trial involved 74 patients at seven centers who each received four doses of stem cells over a period of four weeks. Patients with response rates after the first month continued to receive infusions.
“After 12 months, our evaluations showed that the overall response rate was 28.4 percent, with 6.8 percent complete responses and 21.6 percent partial response,” Dr. Xiao reported. “At 17 months, the overall survival of the initial 74-patient group was 87.8 percent. Seven patients developed transitory and mild headache and fever, but no other adverse events were observed.”
“Our study strongly indicates that MSC infusion is a promising therapy for severe AA, but improved MSC cultures in vitro and the MSC doses need further study to maximize their therapeutic potential," added Dr. Pang.
“This phase II clinical study, involving 74 patients, is significant because it suggests that a stem cell transfusion can be used to treat aplastic anemia that is non-responsive to first-line therapies. The advantages of the treatment are its safety and costs,” said Anthony Atala, M.D., Editor-in-Chief of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine.
About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.
About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://www.StemCells.com), celebrating its 35th anniversary, is the world's first journal devoted to this fast paced field of research. The Oncologist® (http://www.TheOncologist.com), also a monthly peer-reviewed publication, in its 22nd year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.