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Scientists pinpoint melanoma’s origin

A team of researchers has tracked down the cellular origin of cutaneous melanoma, the deadliest form of skin cancer. They observed that these very aggressive tumors arise from mature, pigment-producing cells called melanocytes.

As melanoma develops, these cells are eventually reprogrammed, lose their differentiated features and become invasive, migratory cancer cells. This knowledge is vital to understanding how these melanoma lesions are formed, facilitate their early detection and develop preventive treatment avenues.

Growing human brain cells in the lab

Li Gan, Ph.D., wants to find treatments to help patients with Alzheimer’s disease. Like most researchers, she’s hit a few major roadblocks.

When researchers like Dr. Gan find potential new drugs, it's useful to test them on human cells to increase the chances that they will benefit patients. Historically, these tests have been conducted in cancer cells, which often don’t match the biology of human brain cells.

Battling Lung Fibrosis with Allogeneic Lung Spheroid Cells

In the search for more effective treatment strategies for lung disease, a team of researchers highlights the potential utility of allogeneic adult lung spheroid cells

Organ-Specific “Tissue Papers” Created from Extracellular Matrix Ink

Researchers have developed a new means to utilize decellularized extracellular matrix in regenerative strategies including the maintenance of ovarian tissue 

What’s the Stem Cells Buzz this Week? - Enhanced RGC Generation, Bladder Tissue Engineering, Placental MSC-Treatment of Cardiomyopathy, and MSC-EVs Enhance Survival after Irradiation!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

Worm study reveals role of stem cells in cancer

A new study carried out by the University of Oxford has used flat worms to look at the role of migrating stem cells in cancer.

Researchers in the lab of Aziz Aboobaker, Ph.D., in the Department of Zoology, used the worms (planarians), which are known for their ability to regenerate their tissues and organs repeatedly. This process is enabled by their stem cells, which constantly divide to make new cells.

What’s the Stem Cells Buzz this Week? - Naming MSCs, NHIE Cell Therapy, mESCs go “Surfen”, and Promoting Tendon Differentiation with Fos!

The Stem Cells Portal brings you a roundup of some of the new and exciting stories in the ever-changing world of stem cells, regenerative medicine, and beyond!

New research on sperm stem cells has implications for male infertility and cancer

New research has shed light on the complex process that occurs in the development of human sperm stem cells. This study is reportedly the first to characterize the changes human sperm stem cells undergo as they mature.

The results have implications for understanding male infertility as well as cancer development.

Gene therapy halts progression of deadly CALD in clinical trial

In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) — a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis — effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital reported.

Preclinical Assessment for hESC-derived Oligodendrocyte Progenitor Cells for Cervical Spinal Cord Injury

An exciting new animal study suggests that oligodendrocyte progenitor cells derived from human ESCs are safe for the treatment of cervical spinal cord injury

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