"We had already discovered how VD3 increases the transforming growth factor TGF-ß2 and alkali-phosphatase activity — two essential features of hair-inducing DPCs. This time we focused on VD3's therapeutic potency and values for hair regeneration," said Kotaro Yoshimura, M.D. "The results suggest that it may be useful in expanding human DPCs with good quality, and help establish a DPC transplantation therapy for growing hair."
Yoshimura and Noriyuki Aoi, M.D., both of the University of Tokyo (UT) School of Medicine, led scientists from UT, Osaka University and the Japan Science and Technology Agency in the investigation. After running more tests on how VD3 affected another crucial element for hair growth called Wnt10b gene expression, they collected DPCs from volunteers who had undergone facelifts, incubated the DPCs with VD3 and then grafted them onto hairless skin samples taken from rats.