“Advances in the use of bone marrow stem cells taken from the patient opens up new opportunities for exploring organ replacement therapies, especially for bladder regeneration”, said Sharma. “Several findings from our study have demonstrated the plasticity of stem cells from bone marrow which make them ideal for this type of work.”
The team discovered that bone marrow mesenchymal stem cells (MSCs) have phenotypic and physiological similarities with bladder smooth muscle cells (bSMCs) implying that MSCs can serve as an alternative cell source for potentially damaged bSMCs.
“For our research we developed a primate-based model, using a baboon bladder in conjunction with bone marrow MSCs to attempt partial bladder regeneration,” said Sharma. “We found that the mesenchymal stem cells used throughout the study retained the ability to populate a surgically grafted area while remaining active 10 weeks after surgery.”