Prox1 gene has long been known to play an important role in fetal development. Finnish researchers have now discovered that Prox1 is essential also for skeletal muscle stem cell differentiation.
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Coverage of the latest news and updates from ongoing clinical trials from various sources.
Most lines of human pluripotent stem cells (hPSC) reported worldwide are derived from people or embryos with European or East Asian ancestries.
Columbia College of Dental Medicine researchers have identified stem cells that can make new cartilage and repair damaged joints.
Extensive biosafety studies of hematopoietic stem cell (HSC) gene therapy, intended to replace a protein that patients with the inherited disease mucopolysaccaridosis I (MPS I) cannot produce, support clinical testing of the stem cell-based gene addition approach in MPS I patients.
New research from the University of Minnesota reveals endoglin as a critical factor in determining the fate of early undifferentiated cells during development. Endoglin, a receptor involved in cell signaling, has previously been known mostly for its function in blood vessels and angiogenesis.
Athletes, the elderly and those with degenerative muscle disease would all benefit from accelerated muscle repair. When skeletal muscles (those connected to the bone) are injured, muscle stem cells wake up from a dormant state and repair the damage.
Many diseases that lead to blindness, such as glaucoma and macular degeneration, are caused by the death of certain cells in the human retina that lack the ability to regenerate.
Cancer stem cells resist therapy and are a major cause of relapse, long after the bulk of a tumor has been killed.
Although targeted drugs have revolutionized the treatment of chronic myelogenous leukemia (CML), patients generally must take them for the rest of their lives and may cease benefiting from them over time.
The promise of stem cells to treat cardiovascular disease may soon be a step closer to clinical application as scientists from three institutions seek to perfect and test three-dimensional (3D) "heart patches" in a large animal model — the last big hurdle before trials in human patients.