Researchers at the National Cancer Institute discovered that cells obtained from the lungs of CD47-deficient mice, but not from ordinary mice that have the CD47 gene, multiplied in a culture dish and spontaneously converted into stem cells.
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Coverage of the latest news and updates from the field of stem cells.
All of these patients receiving the stem cell treatment experienced statistically significant improvement in cardiac function and in their ability to walk distances than another group of patients who were given the standard treatments for heart failure.
The works could eventually lead to cell therapies for diseases like inherited leukodystrophies — disorders of the brain's white matter — and multiple sclerosis, as well as spinal cord injuries. Without myelin to insulate neurons, signals sent down nerve cell axons quickly lose power.
“We’re trying to understand how material signals can dictate stem cell response,” said Jason Burdick, a bioengineer in the university’s School of Engineering and Applied Science.
AIFA had closed the Stamina Foundation's laboratories after an inspection last year, saying the company “could not be trusted to produce contamination-free cells.” This action led to a series of legal challenges by parents hoping to obtain the treatment for their children.
“What Atala and his tissue regenerators do and seek to do is, quite simply, in another realm of science and understanding altogether, born of the genius decoded from our own cells,” journalist Tyler Cabot writes in the Esquire article.
Cytori makes the Celution and StemSource devices, which separate adult stem cells from fat tissue using a combination of spinning motions and chemical reactions.
The cells will be genetically identical to the people who donated the samples, and will provide a way for researchers to study those diseases.
"To date, all stem cell trials in the cardiac space use bone marrow and adipose tissue sources.
Human and animal trials in which stem cells were injected into cardiac tissue to treat severe heart attacks or substantial heart failure have largely yielded poor results.