The technique used by Dr. Mitalipov, Paula Amato, M.D., and their colleagues in OHSU’s Department of Obstetrics & Gynecology, is a variation of a commonly used method called somatic cell nuclear transfer, or SCNT.
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Coverage of the latest news and updates from the field of stem cells and regenerative medicine.
“There is a widely held misconception that the adult nervous system is static or fixed, and has a limited capacity for repair and regeneration,” said Dwight Bergles, Ph.D., professor of neuroscience and otolaryngology at the Johns Hopkins University School of Medicine.
“The most amazing thing, which for a little girl is a miracle, is that this transplant has not only saved her life, but it will eventually enable her to eat, drink and swallow, even talk, just like any other normal child,” said Paolo Macchiarini, M.D., Ph.D., professor of regenerative surgery at
When the protein, called GDF-11, was injected into old mice that had developed thickened heart walls in a manner similar to aging humans, the hearts were reduced in size and thickness, resembling the healthy hearts of younger mice.
People with A-T begin life with neurological deficits that become devastating through progressive loss of function in the cerebellum, which leads to severe difficulty with movement and coordination.
“What is unique about this approach is that the native organ’s architecture is preserved, so that the resulting graft can be transplanted just like a donor kidney and connected to the recipient’s vascular and urinary systems,” said Harald Ott, M.D., of the Mass General Center for Regenerative Med
“We are describing a marker called Cd1d,” says CSHL research investigator Camila Dos Santos, Ph.D., the paper’s first author. The marker, also present at the surface of specialized immune cells, is expressed on the surface of a defined population of mammary cells in both mice and humans.
Researchers at the National Cancer Institute discovered that cells obtained from the lungs of CD47-deficient mice, but not from ordinary mice that have the CD47 gene, multiplied in a culture dish and spontaneously converted into stem cells.
All of these patients receiving the stem cell treatment experienced statistically significant improvement in cardiac function and in their ability to walk distances than another group of patients who were given the standard treatments for heart failure.
The works could eventually lead to cell therapies for diseases like inherited leukodystrophies — disorders of the brain's white matter — and multiple sclerosis, as well as spinal cord injuries. Without myelin to insulate neurons, signals sent down nerve cell axons quickly lose power.