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Stem cells from hair follicles have potential to repair damaged neurons in mice

BALTIMORE, MD (US), April 2019 — A subset of the stem cells in hair follicles have the potential to regenerate the coating that insulates neurons in mice, according to a study led by Thomas Hornyak, M.D., Ph.D., of the VA Maryland Health Care System and the University of Maryland School of Medicine. The findings, published in PLOS Genetics, offer a new direction for finding therapeutic options for certain neurodegenerative diseases.

Hair and skin take on varying shades of red, brown, black and yellow due to the pigments produced by cells called melanocytes. Melanocytes originate embryonically from cells called neural crest cells, which are cells that can also give rise to neurons and their supporting glial cells. Previously, Dr. Hornyak and colleagues identified two different pockets of stem cells that create melanocytes inside mature hair follicles. In the current study, they show that the two groups of the melanocyte stem cells can be identified and separated based on whether they are coated in a glycoprotein called CD34, a surface molecule present on other types of stem cells, including stem cells of the blood.

Using hair follicles from mice, the researchers isolated the two populations of melanocyte stem cells and grew them in culture. They were surprised to find that the cells carrying CD34 turn into glial cells. In the nervous system, glial cells coat neurons with a fatty insulation called myelin, which increases the speed that nerve impulses can travel. Furthermore, the researchers discovered that the CD34-positive stem cells could regenerate myelin on neurons, both in cell cultures and when injected into mice carrying a genetic defect that prevents them from forming myelin sheaths.

The new findings suggest that the pocket of CD34-positive melanocyte stem cells in the hair follicle retain some of their earlier abilities. If similar populations exist in human hair follicles, they potentially could be tapped to develop new treatments for nerve injuries and for demyelinating diseases, such as multiple sclerosis.

"In the future, we plan to continue our research in this area by determining whether these cells can enhance functional recovery from neuronal injury," Dr. Hornyak said, "and leverage genome-wide information we have described in the current study to identify similar cells in human skin."

 

Melanocyte stem cells from the telogen, or resting, phase of the mouse hair follicle (green, left panel) within the CD34-positive bulge region (red, left panel) differentiate and form dense myelin sheaths (right panel) in the brain of myelin-deficient mice. Image courtesy of Sandeep Joshi, University of Maryland School of Medicine.

Learn more:
https://www.eurekalert.org/multimedia/pub/198708.php
DOI: 10.1371/journal.pgen.1008034