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Leukemia, breast, and ovarian cancer stem cells



This virtual issue is devoted to leukemia, breast cancer stem cells, and ovarian cancer stem cells. Theoretical aspects of transplantation, analysis of clinical data, and the use of hematopoietic stem cell transplantation in acute myeloid leukemia are discussed. Key aspects of the role of breast cancer stem cells in the pathogenesis of breast cancer are examined in articles devoted to breast cancer initiation, progression, and therapy. Factors affecting intratumoral heterogeneity, invasion, and migration of ovarian cancer cells are examined.

Concise review: Cancer stem cells and minimal residual disease
Ghiaur G, Gerber J, Jones RJ

Concise review: the role of hematopoietic stem cell transplantation in the treatment of acute myeloid leukemia
Hamilton BK, Copelan EA

Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling
Despeaux M, Chicanne G, Rouer E, De Toni-Costes F, Bertrand J, Mansat-De Mas V, Vergnolle N, Eaves C, Payrastre B, Girault JA, Racaud-Sultan C

Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia
Cleveland SM, Smith S, Tripathi R, Mathias EM, Goodings C, Elliott N, Peng D, El-Rifai W, Yi D, Chen X, Li L, Mullighan C, Downing JR, Love P, Dave UP

TEL (ETV6)-AML1 (RUNX1) initiates self-renewing fetal pro-B cells in association with a transcriptional program shared with embryonic stem cells in mice
Tsuzuki S, Seto M

Self-renewal of leukemia stem cells in Friend virus-induced erythroleukemia requires proviral insertional activation of Spi1 and hedgehog signaling but not mutation of p53
Hegde S, Hankey P, Paulson RF

Radiation-induced reprogramming of breast cancer cells
Lagadec C, Vlashi E, Della Donna L, Dekmezian C, Pajonk F

P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer
Vieira AF, Ricardo S, Ablett MP, Dionisio MR, Mendes N, Albergaria A, Farnie G, Gerhard R, Cameselle-Teijeiro JF, Seruca R, Schmitt F, Clarke RB, Paredes J

Mevalonate metabolism regulates Basal breast cancer stem cells and is a potential therapeutic target
Ginestier C, Monville F, Wicinski J, Cabaud O, Cervera N, Josselin E, Finetti P, Guille A, Larderet G, Viens P, Sebti S, Bertucci F, Birnbaum D, Charafe-Jauffret E

Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway
Yang J, Liao D, Chen C, Liu Y, Chuang TH, Xiang R, Markowitz D, Reisfeld RA, Luo Y

ROCK1 inhibition promotes the self-renewal of a novel mouse mammary cancer stem cell
Castro DJ, Maurer J, Hebbard L, Oshima RG

Intravital imaging of cancer stem cell plasticity in mammary tumors
Zomer A, Ellenbroek SI, Ritsma L, Beerling E, Vrisekoop N, Van Rheenen J

Remodeling of endogenous mammary epithelium by breast cancer stem cells
Parashurama N, Lobo NA, Ito K, Mosley AR, Habte FG, Zabala M, Smith BR, Lam J, Weissman IL, Clarke MF, Gambhir SS

Histone deacetylase inhibitors stimulate dedifferentiation of human breast cancer cells through WNT/beta-catenin signaling
Debeb BG, Lacerda L, Xu W, Larson R, Solley T, Atkinson R, Sulman EP, Ueno NT, Krishnamurthy S, Reuben JM, Buchholz TA, Woodward WA

Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts
Zhu C, Cheng KW, Ouyang N, Huang L, Sun Y, Constantinides P, Rigas B

Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers
Stratford AL, Reipas K, Hu K, Fotovati A, Brough R, Frankum J, Takhar M, Watson P, Ashworth A, Lord CJ, Lasham A, Print CG, Dunn SE

Intratumoral heterogeneity in the self-renewal and tumorigenic differentiation of ovarian cancer
Abelson S, Shamai Y, Berger L, Shouval R, Skorecki K, Tzukerman M

Autocrine CCL5 signaling promotes invasion and migration of CD133+ ovarian cancer stem-like cells via NF-kappaB-mediated MMP-9 upregulation
Long H, Xie R, Xiang T, Zhao Z, Lin S, Liang Z, Chen Z, Zhu B