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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

November 23, 2010 | Pluripotent Stem Cells

From this month’s edition of Stem Cells

By Carla Mellough

Elucidation of the best methods for somatic cell reprogramming which fully harness the stem cell-like capacity of induced pluripotent stem cells (iPSCs) is key prior to the utilisation of iPSC for regenerative medicine purposes. The translation of iPSC therapy from the bench to the...

November 12, 2010 | Hair Follicle Stem Cells

From Cancer Research

The microRNA miR-302 is implicated in the regulation of stemness and pluripotency, somatic cell reprogramming and more recently the global DNA demethylation and histone methylation which occurs during somatic cell reprogramming (see Splitting hairs: Follicking about with mir-302). Results from the same group in California now published in Cancer Research go...

November 11, 2010 | Cord Blood Stem Cells

Dr. Cinzia Rota wins Annual Young Investigator Award at International Stem Cell Symposium

Durham, NC & Seoul, Korea, November 2010 - The journal STEM CELLS has announced Dr. Cinzia Rota as the winner of the annual STEM CELLS Young Investigator Award. Co-sponsored by the International Stem Cell Symposium, the $10,000 prize is annually given to a young...

November 10, 2010 | Hepatic Stem Cells

From various news sources

“Liver disease kills more people in the UK than diabetes and road deaths combined, claiming more than 16,000 lives in 2008. It is the only cause of death that is still increasing year-on-year. Numbers of liver disease deaths have increased by 12% since 2005. Last year around 644 liver transplants from deceased donors were carried out...

November 10, 2010 | Hair Follicle Stem Cells

By Carla Mellough

Continuing on with our recent focus on microRNA (miRNA) and induced pluripotency (see ‘Reprogramming the methods that induce pluripotency’), a recent article published in the September advance issue of Nucleic Acids Research from David Wu’s group (WJWU and LYNN Institute for Stem Cell Research) in California may shed light on the mechanisms that govern somatic...

November 3, 2010 | Pluripotent Stem Cells

By Carla Mellough

The clinical applicability of induced pluripotent stem cells (iPSC) has been limited by the inefficiency of reprogramming methods, modification of the genome using most reprogramming protocols, and the lack of failsafe differentiation protocols to then generate functional differentiated phenotypes from iPSCs to provide patient-specific cell types for...

November 1, 2010 |

by Carla B. Mellough

MicroRNAs (miRNAs) are endogenous RNAs that direct the repression of protein coding genes. The way in which miRNAs elicit their effects on protein production has been an issue of great debate, whether they act to decrease translational efficiency, decrease messenger RNA (mRNA) levels or both. Recent results published in Nature from the laboratory of David...

October 26, 2010 | Pluripotent Stem Cells

By Stuart P Atkinson

Non-viral genetic modification of cells is a relatively inefficient process, be it modifying adult cells or in the generation of induced pluripotent stems cells (iPSC). It has been suggested that transposon-based methods of gene transfer may overcome this limitation, but this technique has been plagued by inefficiency problems. However recent work has...

October 26, 2010 | Pluripotent Stem Cells

We all know that vitamin C is important for keeping us healthy through its many activities including its capacity as an antioxidant and its involvement as an enzyme co-factor in collagen synthesis. Indeed this second property is the basis of the most obvious consequence of vitamin c deficiency that was the demise of many an eighteenth century mariner known as Scurvy which messes up the...

October 26, 2010 | Pluripotent Stem Cells

By Stuart P. Atkinson

Gene by gene, we are beginning to unravel and understand those members of the pluripotency network which give embryonic stem cells (ESCs) their identity. Other than giving us an understanding of the molecular networks, signalling pathways and regulatory mechanisms which exist in ESCs, such knowledge is also allowing us to make more and more critical...