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Article Scans

Brief reviews of recently published articles, organized by stem cell type.

March 22, 2011 |

From the March 2011 Issue of Stem Cells

Paper Commentary by Carla Mellough

Mitochondrial function is understood to play a key role in the ageing process and mitochondrial dysfunction underlies the pathophysiology of various diseases. Whilst much attention has focused on the role of the genetic and epigenetic state on cell function and...

March 8, 2011 | Society

From Nature News

The Stem Cell Portal has recently reported on new studies which demonstrate a potential cure for HIV/AIDs based around the CCR5 receptor (Stem Cell Cures for HIV?). It is known that HIV can infect CD4+ T cells through the CCR5 cell surface receptor and the subsequent destruction of the immune system is driven by this loss of normal CD4+ T cells. It has been...

March 8, 2011 | Pluripotent Stem Cells

From the laboratory of Axel Schambach in Germany comes a report describing a system which can be utilized to study the subtle dynamics of early reprogramming. Published in Molecular Therapy, Warlich et al. demonstrate the use of specially engineered colour-coded lentiviral vectors containing reprogramming factors (Oct4, Klf4, Sox2 and c-Myc) under the control of a retroviral promoter...

March 8, 2011 | Pluripotent Stem Cells

From the Journal of Biological Chemistry

Since the generation of the first induced pluripotent stem cells (iPSC) from somatic cells was reported in 2006, various alternative ways of achieving pluripotency have been attempted in order to improve the safety and efficiency of the reprogramming process and of the resultant iPSC. The production of the viral particles commonly used...

February 16, 2011 | Neural Stem Cells

Article Focus for this Month’s Edition of Stem Cells

Paper commentary by Carla B. Mellough

The subventricular zone (SVZ) is a multicellular structure that lines the lateral walls of the lateral ventricles of the brain. SVZ ependymal cells face the ventricular lumen and are involved in the production and circulation of cerebrospinal fluid....

February 15, 2011 | Pluripotent Stem Cells

From the February 2011 Issue of Stem Cells

Paper commentary by Stuart Atkinson

Recently, the Polycomb repressor complex PRC2 and its known constituents (notably Jarid2 and Pcl2 (or Mtf2)) have received an appraisal of their roles in the pluripotent nature and differentiation of embryonic stem cells (ESC) (Reviewed in Margueron and Reinberg). PRC2 is known to...

February 15, 2011 | Pluripotent Stem Cells

From the February 2011 Issue of Stem Cells

Paper commentary by Stuart Atkinson

The correct and efficient differentiation of pluripotent cell types to clinically relevant cell types is a major common goal in stem cell biology. Recent advances in induced pluripotent stem cell (iPSC) technologies have put the prize of patient-specific stem cells for autologous...

February 10, 2011 | Pluripotent Stem Cells

From Nature

A recent report in Nature (Lister et al.) has suggested that human induced pluripotent stem cells (iPSC), the great hope for personalised cellular therapy, are not as similar to embryonic stem cells (ESCs) as hoped, and that this may affect their use as a replacement for ESC in disease modelling and cellular therapy.

Centromeric and...

February 1, 2011 | Haematopoetic Stem Cells

New results from the laboratory of Camilla Forsberg at the Institute for the Biology of Stem Cells, University of Santa Cruz, California are beginning to unravel the mechanisms by which transplanted haematopoietic stem cells (HSCs) localise to the bone marrow niche. HSC transplants are a common treatment for various illnesses including certain blood cancers and their correct localisation is...

January 27, 2011 | Neural Stem Cells

It has been over ten years since the physiological link between nutritional input and growth and development in Drosophila was established, yet the mechanisms downstream of nutritional stimuli that act to regulate the growth of the organism were unknown. Results published recently in Cell from Chell and Brand at the Gurdon Institute and Department of Physiology, Development and...