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Brief reviews of recently published articles, organized by stem cell type.

January 25, 2011 | Hair Follicle Stem Cells

While not being a life threatening condition, male pattern baldness affects (or will affect!) a great number of males and can also affect females too. A recent study in the Journal of Clinical Investigation by Garza et al., from the lab of George Cotsarelis at the University Of Pennsylvania School Of Medicine places the blame for this condition squarely at the feet of our stem cells...

January 25, 2011 | Society

Canadian stem cell pioneer Ernest Armstrong McCulloch has died at the age of 84. Born in Toronto on the 26th of April 1926 McCulloch, affectionately known as ‘Bun’, and his partner James Till were the first to demonstrate the existence of stem cells in the hematopoietic system in the 1960s. Their discovery revolutionized cell biology and cancer therapy and paved the way for the...

January 6, 2011 | Hair Follicle Stem Cells

By Stuart P. Atkinson

Many laboratories throughout the world are working with embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) as sources of cells for replacement therapy in human disease. The necessity for patient specificity of these cells is generally a significant problem, which may be overcome in the case of iPSCs if they ultimately prove to be a...

January 6, 2011 | Pluripotent Stem Cells

By Stuart P. Atkinson

Current protocols for the differentiation of embryonic stem cells (ESC) to clinically relevant cell types are woefully inefficient with many millions or tens of millions of ESC used for each differentiation, only to yield small proportions of the desired cell type. This entails large scale culture and amplification of ESC, often over a large period of...

December 9, 2010 | Pluripotent Stem Cells

From the December Issue of Stem Cells

By Stuart P Atkinson

Modifications of histone proteins have been well studied in ESCs and iPSCs and we are beginning to understand the importance that these modifications have in relation to chromatin structure and gene regulation and indeed the enzymes which mediate these modifications. However, research into...

December 9, 2010 | Pluripotent Stem Cells

From Cell Stem Cell

A new study from the lab of Sheng Ding (The Scripps Research Institute), published recently in Cell Stem Cell, reports the reprogramming of human primary somatic cells using only OCT4 gene transduction and a combination of small molecules. Kim et alhad previously shown than one factor reprogramming is possible, but in human foetal...

November 26, 2010 | Society
By Marie McCullough
Inquirer Staff Writer

Is it legal for the federal government to fund human embryonic stem cell research?

Next month, a federal appeals court will hear...
November 26, 2010 | Pluripotent Stem Cells

by Stuart P. Atkinson

From the lab of Dan Kaufman at the Department of Medicine and Stem Cell Institute, University of Minnesota comes a report on the potential use of patient specific human induced pluripotent stem cells (hiPSCs) in the battle against HIV-1 infection. Kaufman’s lab have previously shown that embryonic stem cell (ESC) derived Natural Killer (NK) cells, a key...

November 24, 2010 | Pluripotent Stem Cells

By Stuart P. Atkinson

Little by little, the processes behind cellular reprogramming of lineage-committed cells to induced pluripotent stem cells (iPSCs) are being discovered and more detailed comparative studies between iPSC and embryonic stem cells (ESCs) are being undertaken. The similarity of these two cell types is generally viewed as being essential if hiPSCs are to be...

November 23, 2010 |

From this month’s edition of Stem Cells

By Carla Mellough

One of the limiting factors in the race to replenish ageing, damaged or dysfunctional cells by cell transplantation is the longevity of engrafted replacement cell types within host tissue. Results published in this month’s edition of Stem Cells from the laboratory of...

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