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Brief reviews of recently published articles, organized by stem cell type.

April 13, 2011 | Pluripotent Stem Cells

From the April 2011 Issue of Stem Cells

Paper Commentary by Stuart P. Atkinson

HOX genes are a group of related genes that act to determine the basic structure and orientation of an organism and contain a DNA-binding domain called the homeodomain which can bind to enhancer sequences of other genes to control their transcription. Many HOX genes...

April 13, 2011 | Pluripotent Stem Cells

From the April 2011 Issue of Stem Cells

Paper Commentary by Stuart P. Atkinson

The gastrula organizer, a structure first described in the amphibian by Spemann and Mangold in 1923, contains a population of organizer cells which signal the allocation of anterior versus posterior structures and axis formation in the developing vertebrate embryo. It...

April 11, 2011 | Haematopoetic Stem Cells

From the Journal of Clinical Investigation

Results from a recent study published in the Journal of Clinical Investigation by Shiozawa et al. from the University of Michigan and Harvard School of Dental Medicine provide new evidence for the mechanisms directing metastases of carcinomas into bone tissue, observed in 70% of patients with breast or prostate cancer and up to 30% of...

March 30, 2011 | Pluripotent Stem Cells

Review by Stuart P. Atkinson

Recent studies in embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) biology have turned from comparative studies at the RNA and chromatin level to focus on what’s happening at the DNA level (See iPSC don´t Forget their Origins and Another Blow to the iPSC Field?). Genomic integrity is of course vital for the future use of such...

March 23, 2011 | Pluripotent Stem Cells

From the March 2011 Issue of Stem Cells

Paper Commentary by Stuart P. Atkinson

Induced pluripotent stem cells (iPSC) have the potential to provide a patient specific source of cells that can be used in cellular therapy. However doubts about their similarity to embryonic stem cells (ESCs) have arisen, both at the gene expression and epigenetic...

March 23, 2011 | Pluripotent Stem Cells

From the March 2011 Issue of Stem Cells

Paper Commentary by Carla Mellough

Mitochondrial function is understood to play a key role in the ageing process and mitochondrial dysfunction underlies the pathophysiology of various diseases. Whilst much attention has focused on the role of the genetic and epigenetic state on cell function and...

March 23, 2011 | Pluripotent Stem Cells

From the March 2011 Issue of Stem Cells

Paper Commentary by Stuart P. Atkinson

The RNA binding protein LIN28 (or LIN28A) is highly expressed in human embryonic stem cells (hESCs) and is often used in the generation of induced pluripotent stem cells (iPSCs) (Yu et al.). It is known to play a role in inhibiting the maturation and...

March 22, 2011 | Pluripotent Stem Cells

From the March 2011 Issue of Stem Cells

Paper Commentary by Carla Mellough

Original reports describing the generation of induced pluripotent stem cells (iPSCs) set the foundations of the reprogramming process as the exogenous expression of four transcription factors Oct4, Sox2, Klf4, c-Myc and/or Lin28...

March 22, 2011 |

From the March 2011 Issue of Stem Cells

Paper Commentary by Carla Mellough

Mitochondrial function is understood to play a key role in the ageing process and mitochondrial dysfunction underlies the pathophysiology of various diseases. Whilst much attention has focused on the role of the genetic and epigenetic state on cell function and...

March 8, 2011 | Society

From Nature News

The Stem Cell Portal has recently reported on new studies which demonstrate a potential cure for HIV/AIDs based around the CCR5 receptor (Stem Cell Cures for HIV?). It is known that HIV can infect CD4+ T cells through the CCR5 cell surface receptor and the subsequent destruction of the immune system is driven by this loss of normal CD4+ T cells. It has been...

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