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Brief reviews of recently published articles, organized by stem cell type.

January 4, 2012 | Mesenchymal Stem Cells

Original article from STEM CELLS

Recent studies have demonstrated that mesenchymal stem cells (MSCs) have the ability to differentiate into various kinds of cell types, including neuron-like cells in culture (Woodbury et al, Qian and Saltzman, Levy et al and Rismanchi...

January 4, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Current knowledge of the mechanisms of neural induction in mammals is not clear, but data from other model systems has allowed some details to be uncovered. Examinations on mammalian neural induction are mostly performed using in vitro models of neuroepithelial differentiation from embryonic stem cells (ESCs) and confirm...

January 4, 2012 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

In mouse, Pten plays a negative role in the self-renewal of embryonic and adult cell types (Stiles et al, Korkaya et al and Groszer et al) through negative regulation of PI3K/Akt signalling and while studies have shown the importance of PI3K/Akt signalling in embryonic stem cells (ESCs) (Ding et al and...

December 13, 2011 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

The ability to monitor the homogeneity of pluripotent cell cultures and their differentiated derivatives is potentially useful if such cells are to be made applicable to cellular therapy. Another use for such monitoring systems is in the generation of pure induced pluripotent stem cultures (iPSCs) containing only fully reprogrammed...

December 13, 2011 | Direct Reprogramming

From Cell Stem Cell
By Stuart P. Atkinson

Direct conversion of one somatic cell to another somatic cell type, completely bypassing the pluripotent stage through the forced expression of lineage specific transcription factors has emerged as a large “splinter group” of research, taking many lessons from induced pluripotent stem cell (iPSC) technology. The direct generation...

December 13, 2011 | Pluripotent Stem Cells

From Stem Cells
By Stuart P. Atkinson

Induced pluripotent stem cell (iPSC) technology not only has the capability to produce patient-specific but also disease-specific pluripotent cells. In monogenic diseases, there lies the potential for gene modification allowing differentiation of therapeutically relevant “corrected” cells, as has been demonstrated in mouse iPSCs...

December 13, 2011 | Pluripotent Stem Cells

From Cell
By Stuart P. Atkinson

Although multiple studies over the last 5-10 years have begun to unravel the complex network which underlies the pluripotent state of embryonic stem cells (ESCs), bringing together transcription factors, small RNA species, chromatin and DNA methylation events, the specific molecular determinants of the pluripotent state are yet to be fully...

November 18, 2011 | Direct Reprogramming

From PNAS
By Carla Mellough

It is just 5 years since Takahashi and Yamanaka demonstrated that both embryonic and adult mouse somatic cells could be reprogrammed back to a pluripotent state, creating induced pluripotent stem cells (iPSCs). In the short time since this achievement the equivalent has been demonstrated across multiple human somatic cell types, which has...

November 10, 2011 | Pluripotent Stem Cells

From the October Edition of Stem Cells
By Stuart P. Atkinson

A brief report in the October edition of Stem Cells from the laboratory of Steven L. Stice at the University of Georgia, Athens, Georgia, USA describes the ability of pig induced pluripotent stem cells (piPSCs) to be transmitted through the germline and studies the effect of piPSC incorporation on offspring...

November 10, 2011 | Epiblast Stem Cells

From the October Edition of Stem Cells
By Stuart P. Atkinson

Epiblast stem cells (EpiSCs) are derived from postimplantation mouse embryos from embryonic day (E) 5.5 to E7.5 (Brons et al and Tesar et al) and appear to share more characteristics with human embryonic stem cells (hESCs) than with mouse ESCs (mESCs) (Greber et al). EpiSCs are...

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