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Brief reviews of recently published articles, organized by stem cell type.

May 23, 2011 | Pluripotent Stem Cells

From the June 2011 Issue of Stem Cells
Paper Commentary by Stuart P. Atkinson

A safe and accessible source of somatic cells which are amenable to reprogramming and the generation of induced pluripotent stem cells (iPSCs) is currently very much sought after. While some adult stem cell sources are readily reprogrammable with one or two factors, neural progenitor cells are...

May 23, 2011 | Pluripotent Stem Cells

From the May 2011 Issue of Stem Cells
Paper Commentary by Stuart P. Atkinson

Recent high impact studies have shown that the reprogramming of somatic cells towards pluripotency requires a mesenchymal-to-epithelial transition (MET) (Li et al and Samavarchi-Tehrani et al) which is in part mediated by the function of microRNA (miRNA) species (Liao et al and Subramanyam et al...

May 23, 2011 | Pluripotent Stem Cells

From the June 2011 Issue of Stem Cells
Paper Commentary by Stuart P. Atkinson

The field of induced pluripotent stem cells (iPSCs) grows and expands with every passing day, fuelled by the seemingly graspable prize of a bona fide source of patient-specific pluripotent cells for regenerative medicine, be it for cell replacement therapy, drug screening or developmental...

May 23, 2011 | Pluripotent Stem Cells

From the May 2011 Issue of Stem Cells

Paper Commentary by Carla Mellough

Stem cell therapy remains one of the most promising options for restoration of the degenerative retina. Featured in the May edition of Stem Cells are two articles (Zhou et al. and Kokkinaki et al.) which demonstrate that induced pluripotent stem cells (iPSC) can...

May 23, 2011 | Pluripotent Stem Cells

From the May 2011 Issue of Stem Cells

Paper Commentary by Carla Mellough

Complimentary to another article involving the retina, also featured in the May edition of Stem Cells, the potential for induced pluripotent stem cells (iPSC) to generate replacement retinal components is further demonstrated in an article by Kokkinaki ...

May 23, 2011 | Mammary Stem Cells

By Carla Mellough

The dogma that stem cells exist at the apex of a cellular hierarchy and divide to self-renew as well as generate more differentiated progeny in a unidirectional fashion may now be under question following a recent report published in PNAS. The paper, by Christine...

May 23, 2011 | Pluripotent Stem Cells

From the May 2011 Issue of Stem Cells

Paper Commentary by Stuart P. Atkinson

Dementia, and specifically Alzheimer's disease (AD), may be among the most costly diseases for society in Europe and the United States, and with the continual increase in the aged population promises only to get worse, with 1 in 85 persons worldwide of...

May 12, 2011 | Society

Lyle Armstrong, Stem Cells Portal Editor

Human Stem cell research has never had an easy time in terms of public acceptance and government regulation so workers in this field should be accustomed to controversial decisions affecting the future of this endeavour. Neither is it rare for two areas of the world to hold diametrically opposed views about stem cell research but in...

May 4, 2011 | Pluripotent Stem Cells

From Nature Biotechnology.

Recent correspondence in Nature Biotechnology has suggested that there are no notable differences in the incidence of chromosomal aberrations between ESC and iPSC. The paper (Taapken et al) from Karen D Montgomery of the WiCell Research Institute in Wisconsin analysed 552 cultures of 219 human iPSC lines and 1,163 cultures from 40 human ESC lines...

April 13, 2011 | Pancreatic Stem Cells

From the April 2011 Issue of Stem Cells

Paper Commentary by Stuart P. Atkinson

Pancreatic beta cell replacement for the treatment of type I diabetes mellitus through the directed differentiation of human embryonic stem cells (hESCs) is one of the great hopes for regenerative medicine. Great strides have been made towards this goal, although...

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