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Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer

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Clinical significance of Sca-1 in human gastric cancer. Clinical significance of Sca-1 in human gastric cancer. (A): A hierarchical clustering dendrogram for pretreatment biopsy samples of chemotherapy-treated gastric cancer patients, which was generated using genes overexpressed in Sca-1high S1 cells (Sca-1 signature). Red and green denotes high and low gene expression levels, respectively. (B): Kaplan-Meier plots for overall survival of 2 clusters generated by (A). Patients who overexpressed genes in the Sca-1 signature had significantly shorter overall survival (Log-rank, p = .005). Red and black lines denote Kaplan-Meir plots for clusters with high- and low-expression of genes in the Sca-1 signature, respectively.

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