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Searching for Classical Brown Fat in Humans: Development of a Novel Human Fetal Brown Stem Cell Model

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Brown adipose pads are present in the interscapular region of human fetus. Tissue sections from a representative fetus (12 week gestation). Hematoxylin-eosin staining of fetal interscapular adipose tissue revealed the presence of some dispersed cells with a multilocular aspect, characteristic of brown adipocytes (A–C, arrowheads). Immunohistochemistry on serial sections confirmed the brown nature of the multilocular cells which were positive for the brown marker uncoupling-protein-1 (UCP-1) (E–F). Negative control with unstained multilocular cells (D, arrowheads). Magnification: (A): × 10; (B, D, E): × 20; (C): × 40; (F): × 60.

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