You are here

Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells

Comment

Discuss

Association of Prx II with cancer stem cell in HCC cells. (A): Representative image of EpCAM(+)/K19(+) HCC showing Prx II expression in contrast to EpCAM(−)/K19(−) HCC without expression of Prx II (magnification, × 200). (B): Comparison of proportions of Prx II expressing in EpCAM(+)/K19(+) HCCs and EpCAM(−)/K19(−) HCCs. (C): Expression levels of Sox2 in Huh7 cells transfected with siPrx II. (D): Proportions of 2′,7′-dichlorodihydrofluorescein diacetate, annexin V, EpCAM, and CD133 positive in Huh7 cells transfected with siPrx II by flow cytometric analysis. The data are the mean ± SEM (n = 5 per group), *p < .05. Abbreviations: EpCAM, epithelial-cell adhesion molecules; HCC, hepatocellular carcinoma; Prx II, peroxiredoxin II; K19, cytokeratin 19.

article link: