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Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells



Association of Prx II with cancer stem cell in HCC cells. (A): Representative image of EpCAM(+)/K19(+) HCC showing Prx II expression in contrast to EpCAM(−)/K19(−) HCC without expression of Prx II (magnification, × 200). (B): Comparison of proportions of Prx II expressing in EpCAM(+)/K19(+) HCCs and EpCAM(−)/K19(−) HCCs. (C): Expression levels of Sox2 in Huh7 cells transfected with siPrx II. (D): Proportions of 2′,7′-dichlorodihydrofluorescein diacetate, annexin V, EpCAM, and CD133 positive in Huh7 cells transfected with siPrx II by flow cytometric analysis. The data are the mean ± SEM (n = 5 per group), *p < .05. Abbreviations: EpCAM, epithelial-cell adhesion molecules; HCC, hepatocellular carcinoma; Prx II, peroxiredoxin II; K19, cytokeratin 19.

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