At 1 hour post- traumatic spinal cord injury (SCI), 2.5 million human stromal cells (human umbilical cord matrix cells, HUCMCs; or human brain vascular pericytes, HBVPs) were systemically infused via the tail vein (A). While a majority of cells ended up in the lungs, liver and spleen, the spleen was found to be the site of IL-10 synthesis/release (B). Systemic changes in IL-10 were associated with decreased blood-spinal cord barrier (BSCB) permeability and reduced spinal cord hemorrhage at acute time-points (C). Weekly-standardized behavioural testing revealed that the early protective effects of cell infusion lead to some improvements in functional recovery (D). Together, these data warrant further study of the splenic role in secondary pathology and cell-based reparative mechanisms for future clinical translation.
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Early Intravenous Delivery of Human Brain Stromal Cells Modulates Systemic Inflammation and Leads to Vasoprotection in Traumatic Spinal Cord Injury