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Clinical Trials: Cord Blood

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Body: Conditions:   Acute Leukemia of Ambiguous Lineage;   Adult Acute Myeloid Leukemia in Remission;   Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11;   Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11;   Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1;   Adult Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A;   Adult Acute Promyelocytic Leukemia With PML-RARA;   Alkylating Agent-Related Acute Myeloid Leukemia;   Childhood Acute Myeloid Leukemia in Remission;   Recurrent Adult Acute Myeloid Leukemia;   Recurrent Childhood Acute Myeloid Leukemia;   Untreated Adult Acute Myeloid Leukemia
Interventions:   Drug: Cytarabine;   Procedure: Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion;   Biological: Filgrastim;   Drug: Fludarabine Phosphate
Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   Seattle Children's Research Institute Center for Clinical and Translational Research
Active, not recruiting - verified March 2017
Body: Conditions:   Acute Biphenotypic Leukemia;   Acute Erythroid Leukemia;   Acute Lymphoblastic Leukemia in Remission;   Acute Megakaryoblastic Leukemia;   Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome;   Acute Myeloid Leukemia in Remission;   Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Mixed Phenotype Acute Leukemia;   Myelodysplastic Syndrome;   Myelodysplastic Syndrome With Excess Blasts;   Pancytopenia;   Refractory Anemia;   Secondary Acute Myeloid Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Cyclosporine;   Procedure: Double-Unit Umbilical Cord Blood Transplantation;   Procedure: Ex Vivo-Expanded Cord Blood Progenitor Cell Infusion;   Drug: Fludarabine Phosphate;   Other: Laboratory Biomarker Analysis;   Drug: Mycophenolate Mofetil;   Radiation: Total-Body Irradiation;   Procedure: Umbilical Cord Blood Transplantation
Sponsors:   Fred Hutchinson Cancer Research Center;   National Cancer Institute (NCI);   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2017
Body: Conditions:   Acute Lymphoblastic Leukemia;   Acute Myeloid Leukemia;   Myelodysplastic Syndrome
Interventions:   Drug: Allopurinol;   Drug: Keppra;   Drug: Busulfan;   Drug: Cyclophosphamide;   Drug: Cyclosporine A;   Drug: Mycophenolate mofetil;   Biological: Allogeneic hematopoietic stem cell transplant;   Biological: Filgrastim;   Biological: antithymocyte globulin
Sponsor:   Masonic Cancer Center, University of Minnesota
Recruiting
Body: Conditions:   Leukemia;   Myelodysplastic Syndrome;   Lymphoma
Interventions:   Device: CliniMACS Fractionation system (Arm A);   Device: CliniMACS Fractionation system (Arm B)
Sponsor:   Memorial Sloan Kettering Cancer Center
Recruiting - verified June 2017
Body: Condition:   Infusion Reactions
Intervention:   Biological: unlicensed CBU
Sponsor:   New York Blood Center
Recruiting - verified April 2017
Body: Conditions:   SCID;   Omenn's Syndrome;   Reticular Dysgenesis;   Wiskott-Aldrich Syndrome;   Bare Lymphocyte Syndrome;   Common Variable Immunodeficiency;   Chronic Granulomatous Disease;   CD40 Ligand Deficiency;   Hyper IgM Syndrome;   X-linked Lymphoproliferative Disease;   Hemophagocytic Lymphohistiocytosis;   Griscelli Syndrome;   Chediak-Higashi Syndrome;   Langerhan's Cell Histiocytosis
Interventions:   Drug: Alemtuzumab 0.3 mg;   Drug: Cyclophosphamide;   Drug: Busulfan;   Biological: Stem Cell Transplantation;   Drug: Fludarabine phosphate 40 mg;   Drug: Melphalan;   Drug: Alemtuzumab 0.2 mg;   Drug: Fludarabine phosphate 30 mg;   Drug: MESNA
Sponsor:   Masonic Cancer Center, University of Minnesota
Recruiting
Body: Condition:   Autism
Interventions:   Biological: Autologous Cord Blood Stem Cells;   Biological: Placebo
Sponsor:   Sutter Health
Completed - verified May 2017
Body: Conditions:   Lysosomal Storage Disease;   Peroxisomal Disorder
Interventions:   Drug: Campath-1H;   Drug: Clofarabine;   Drug: Melphalan;   Radiation: Total Body Irradiation with Marrow Boosting;   Biological: Hematopoietic stem cell transplantation;   Drug: Cyclosporine A;   Drug: Mycophenolate mofetil
Sponsor:   Masonic Cancer Center, University of Minnesota
Completed
Body: Condition:   Hematologic Malignancies
Interventions:   Biological: ProHema-CB;   Biological: Untreated CB
Sponsor:   Fate Therapeutics
Terminated - verified June 2017
Body: Conditions:   Degenerative Osteoarthritis;   Defect of Articular Cartilage
Interventions:   Biological: CARTISTEM;   Procedure: Microfracture
Sponsors:   Medipost Co Ltd.;   Dong-A Pharmaceutical Co., Ltd.
Completed - verified April 2017
Body: Condition:   Hematologic Malignancies
Interventions:   Drug: Fludarabine;   Drug: Busulfan;   Drug: Thymoglobulin;   Radiation: Total Body Irradiation;   Biological: Umbilical Cord Blood
Sponsor:   University of Virginia
Terminated
Body: Conditions:   Mucopolysaccharidosis I;   Mucopolysaccharidosis VI;   Adrenoleukodystrophy;   Niemann-Pick Disease;   Metachromatic Leukodystrophy;   Wolman Disease;   Krabbe's Disease;   Gaucher's Disease;   Fucosidosis;   Batten Disease;   Severe Aplastic Anemia;   Diamond-Blackfan Anemia;   Amegakaryocytic Thrombocytopenia;   Myelodysplastic Syndrome;   Acute Myelogenous Leukemia;   Acute Lymphocytic Leukemia
Intervention:   Drug: Human Placental Derived Stem Cell
Sponsor:   New York Medical College
Active, not recruiting
Body: Condition:   Sickle Cell Disease & Thalassemia
Intervention:   Drug: NiCord
Sponsor:   Gamida Cell ltd
Recruiting - verified May 2017
Body: Conditions:   Leukemia;   Lymphoma
Interventions:   Drug: Rituximab;   Drug: 111In Ibritumomab;   Procedure: Planar Scintigraphy Imaging;   Drug: 90Y IbritumomabTiuxetan;   Drug: Fludarabine;   Drug: Bendamustine;   Drug: Thymoglobulin;   Drug: Tacrolimus;   Drug: Methotrexate;   Drug: Mycophenolate;   Drug: G-CSF;   Procedure: Stem Cell Transplantation
Sponsors:   M.D. Anderson Cancer Center;   Spectrum Pharmaceuticals, Inc
Active, not recruiting - verified April 2017
Body: Condition:   Hematologic Malignancies
Intervention:   Biological: StemEx
Sponsors:   Loyola University;   Gamida Cell ltd
Active, not recruiting

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