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Special Neural Stem Cells Virtual Issue

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Special Neural Stem Cells Virtual Issue

Curated by Prof. Noel Buckley and Prof. Terry R.J. Lappin 

This special virtual issue highlights a number of exciting papers published in the Sister Journals over the past two years. By way of introduction, Professor Noel Buckley provides an insightful commentary on the burgeoning field of neural stem cells, focusing on their potential to improve our understanding of neurological disease and to reveal novel therapeutic targets. He goes on to discuss the huge challenges that remain in the design of relevant experimental systems.

The manuscripts selected from Stem Cells and Stem Cells Translational Medicine for this collection illustrate the novelty and diversity of experimental approaches to neurodevelopmental and neurodegenerative disorders currently underway globally.

We hope that you will be both informed and inspired by browsing this Virtual Issue!

Commentary: Neural Stem Cells - Through the Looking Glass


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Neurodegeneration & Aging

Stem Cells

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Aging and Neurodegeneration
Aoife Murray, Audrey Letourneau, Claudia Canzonetta, Elisavet Stathaki, Stefania Gimelli, Frederique Sloan-Bena, Robert Abrehart, Pollyanna Goh, Shuhui Lim, Chiara Baldo, Franca Dagna-Bricarelli, Saad Hannan, Martin Mortensen, David Ballard, Denise Syndercombe Court, Noemi Fusaki, Mamoru Hasegawa, Trevor G. Smart, Cleo Bishop, Stylianos E. Antonarakis, Jürgen Groet and Dean Nizetic

Stem Cells Translational Medicine

Human Neural Stem Cells Survive Long Term in the Midbrain of Dopamine-Depleted Monkeys After GDNF Overexpression and Project Neurites Toward an Appropriate Target
Dustin R. Wakeman, D. Eugene Redmond, Jr., Hemraj B. Dodiya, John R. Sladek, Jr., Csaba Leranth, Yang D. Teng, R. Jude Samulski, Evan Y. Snyder 

Concise Review: Modeling Multiple Sclerosis With Stem Cell Biological Platforms: Toward Functional Validation of Cellular and Molecular Phenotypes in Inflammation-Induced Neurodegeneration
Joshua C. Orack, Michela Deleidi, David Pitt, Kedar Mahajan, Jacqueline A. Nicholas, Aaron L. Boster, Michael K. Racke, Manuel Comabella, Fumihiro Watanabe, Jaime Imitola

Intrastriatal Transplantation of Adult Human Neural Crest-Derived Stem Cells Improves Functional Outcome in Parkinsonian Rats
Janine Müller, Christiana Ossig, Johannes F.W. Greiner, Stefan Hauser, Mareike Fauser, Darius Widera, Christian Kaltschmidt, Alexander Storch,  Barbara Kaltschmidt

Neural Stem Cell Development & Neurodevelopmental Disorders

Stem Cells

Defined Human Pluripotent Stem Cell Culture Enables Highly Efficient Neuroepithelium Derivation Without Small Molecule Inhibitors
Ethan Scott Lippmann, Maria Carolina Estevez-Silva and Randolph Scott Ashton

Modeling Human Retinal Development with Patient-Specific Induced Pluripotent Stem Cells Reveals Multiple Roles for Visual System Homeobox 2
M. Joseph Phillips, Enio T. Perez, Jessica M. Martin, Samantha T. Reshel, Kyle A. Wallace, Elizabeth E. Capowski, Ruchira Singh, Lynda S. Wright, Eric M. Clark, Patrick M. Barney, Ron Stewart, Sarah J. Dickerson, Michael J. Miller, E. Ferda Percin, James A. Thomson and David M. Gamm

Stem Cells Translational Medicine

CXCL12 Gene Therapy Ameliorates Ischemia-Induced White Matter Injury in Mouse Brain
Yaning Li, Guanghui Tang, Yanqun Liu, Xiaosong He, Jun Huang, Xiaojie Lin, Zhijun Zhang, Guo-Yuan Yang, Yongting Wang

Reprogramming

Stem Cells

Concise Review: Generation of Neurons From Somatic Cells of Healthy Individuals and Neurological Patients Through Induced Pluripotency or Direct Conversion
Iván Velasco, Patricia Salazar, Alessandra Giorgetti, Verónica Ramos-Mejía, Julio Castaño, Damià Romero-Moya and Pablo Menendez 

Molecular Evidence for OCT4-Induced Plasticity in Adult Human Fibroblasts Required for Direct Cell Fate Conversion to Lineage Specific Progenitors
Ryan Mitchell, Eva Szabo, Zoya Shapovalova, Lili Aslostovar, Kennedy Makondo and Mickie Bhatia

Defined Human Pluripotent Stem Cell Culture Enables Highly Efficient Neuroepithelium Derivation Without Small Molecule Inhibitors
Ethan Scott Lippmann, Maria Carolina Estevez-Silva and Randolph Scott Ashton 

Glia

Stem Cells

Concise Review: Reactive Astrocytes and Stem Cells in Spinal Cord Injury: Good Guys or Bad Guys?
Dunja Lukovic, Miodrag Stojkovic, Victoria Moreno-Manzano, Pavla Jendelova, Eva Sykova, Shomi S. Bhattacharya and Slaven Erceg

Notch1 Stimulation Induces a Vascularization Switch With Pericyte-Like Cell Differentiation of Glioblastoma Stem Cells
Pierre-Olivier Guichet, Sophie Guelfi, Marisa Teigell, Liesa Hoppe, Norbert Bakalara, Luc Bauchet, Hugues Duffau, Katrin Lamszus, Bernard Rothhut and Jean-Philippe Hugnot

Transplantation

Stem Cells

Daylight Vision Repair by Cell Transplantation
Tiago Santos-Ferreira, Kai Postel, Henrike Stutzki, Thomas Kurth, Günther Zeck and Marius Ader 

Concise Review: Spinal Cord Injuries: How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge?
Virginie Neirinckx, Dorothée Cantinieaux, Cécile Coste, Bernard Rogister, Rachelle Franzen and Sabine Wislet-Gendebien

Stem Cells Translational Medicine

Human Neural Stem Cells Survive Long Term in the Midbrain of Dopamine-Depleted Monkeys After GDNF Overexpression and Project Neurites Toward an Appropriate Target
Dustin R. Wakeman, D. Eugene Redmond, Jr., Hemraj B. Dodiya, John R. Sladek, Jr., Csaba Leranth, Yang D. Teng, R. Jude Samulski, Evan Y. Snyder

Intrastriatal Transplantation of Adult Human Neural Crest-Derived Stem Cells Improves Functional Outcome in Parkinsonian Rats
Janine Müller, Christiana Ossig, Johannes F.W. Greiner, Stefan Hauser, Mareike Fauser, Darius Widera, Christian Kaltschmidt, Alexander Storch,  Barbara Kaltschmidt

Adult Neural Stem Cells

Stem Cells

Running Rescues Defective Adult Neurogenesis by Shortening the Length of the Cell Cycle of Neural Stem and Progenitor Cells
Stefano Farioli-Vecchioli, Andrea Mattera, Laura Micheli, Manuela Ceccarelli, Luca Leonardi, Daniele Saraulli, Marco Costanzi, Vincenzo Cestari, Jean-Pierre Rouault and Felice Tirone

Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population
Claudio Giachino, Onur Basak, Sebastian Lugert, Philip Knuckles, Kirsten Obernier, Roberto Fiorelli, Stephan Frank, Olivier Raineteau, Arturo Alvarez-Buylla and Verdon Taylor

Transcriptional Hallmarks of Heterogeneous Neural Stem Cell Niches of the Subventricular Zone
Kasum Azim, Anahí Hurtado-Chong, Bruno Fischer, Nitin Kumar, Stefan Zweifel, Verdon Taylor and Olivier Raineteau

Stem Cells Translational Medicine

Human Adult White Matter Progenitor Cells Are Multipotent Neuroprogenitors Similar to Adult Hippocampal Progenitors
Xenia Lojewski, Andreas Hermann, Florian Wegner, Marcos J. Araúzo-Bravo, Susanne Hallmeyer-Elgner, Matthias Kirsch, Johannes Schwarz, Hans R. Schöler, Alexander Storch

Isolation of Neural Progenitor Cells From the Human Adult Subventricular Zone Based on Expression of the Cell Surface Marker CD271
Miriam E. van Strien, Jacqueline A. Sluijs, Brent A. Reynolds, Dennis A. Steindler, Eleonora Aronica,  Elly M. Hol

Regeneration

Stem Cells

Concise Review: Spinal Cord Injuries: How Could Adult Mesenchymal and Neural Crest Stem Cells Take Up the Challenge?
Virginie Neirinckx, Dorothée Cantinieaux, Cécile Coste, Bernard Rogister, Rachelle Franzen and Sabine Wislet-Gendebien

Stem Cells Translational Medicine

Human Neural Stem Cells Survive Long Term in the Midbrain of Dopamine-Depleted Monkeys After GDNF Overexpression and Project Neurites Toward an Appropriate Target
Dustin R. Wakeman, D. Eugene Redmond, Jr., Hemraj B. Dodiya, John R. Sladek, Jr., Csaba Leranth, Yang D. Teng, R. Jude Samulski, Evan Y. Snyder

Concise Review: Modeling Multiple Sclerosis With Stem Cell Biological Platforms: Toward Functional Validation of Cellular and Molecular Phenotypes in Inflammation-Induced Neurodegeneration
Joshua C. Orack, Michela Deleidi, David Pitt, Kedar Mahajan, Jacqueline A. Nicholas, Aaron L. Boster, Michael K. Racke, Manuel Comabella, Fumihiro Watanabe, Jaime Imitola

Intrastriatal Transplantation of Adult Human Neural Crest-Derived Stem Cells Improves Functional Outcome in Parkinsonian Rats
Janine Müller, Christiana Ossig, Johannes F.W. Greiner, Stefan Hauser, Mareike Fauser, Darius Widera, Christian Kaltschmidt, Alexander Storch,  Barbara Kaltschmidt

Canine Epidermal Neural Crest Stem Cells: Characterization and Potential as Therapy Candidate for a Large Animal Model of Spinal Cord Injury
Barbara Gericota, Joseph S. Anderson, Gaela Mitchell, Dori L. Borjesson, Beverly K. Sturges, Jan A. Nolta, Maya Sieber-Blum

Target Identification / Drug Screening / Biomarkers

Stem Cells Translational Medicine

Concise Review: Modeling Multiple Sclerosis With Stem Cell Biological Platforms: Toward Functional Validation of Cellular and Molecular Phenotypes in Inflammation-Induced Neurodegeneration
Joshua C. Orack, Michela Deleidi, David Pitt, Kedar Mahajan, Jacqueline A. Nicholas, Aaron L. Boster, Michael K. Racke, Manuel Comabella, Fumihiro Watanabe, Jaime Imitola

Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer’s Disease
Lisa M. McGinley, Erika Sims, J. Simon Lunn, Osama N. Kashlan, Kevin S. Chen, Elizabeth S. Bruno, Crystal M. Pacut, Tom Hazel, Karl Johe, Stacey A. Sakowski, Eva L. Feldman