The capacity of endothelial colony-forming cells (ECFCs) to promote vascular repair and regeneration of the ischemic retina has potential for clinical translation; however, cell transplantation into the eye requires extensive preclinical testing. This study provides supporting evidence to facilitate effective translation into clinics. The authors demonstrated high purity of the ECFC cell product, minimal therapeutic dose, and efficacy using readouts that include in vivo angiography. Toxicity was not observed after ECFC intravitreal delivery into healthy adult eyes. Importantly, this study also showed feasibility of intracarotid delivery for targeting the ipsilateral retina.
This review covers the important role stem cells play in understanding and treating Huntington's disease (HD). The significance of the review is the comprehensive discussion of the range of applications by which stem cells can be applied to HD research and therapy, including manipulation of either endogenous or exogenous stem cell populations. In particular, the advantages and disadvantages of using induced pluripotent stem cells compared with directly reprogrammed neural stem cells for cell replacement therapy is discussed. Furthermore, the therapeutic potential of mesenchymal stem cells is identified. Potential gaps in knowledge and future directions are specifically delineated.
Researchers demonstrate the possibility of enhanced tooth repair via the application of Platelet-Derived Growth Factor-modified human dental pulp stem cells