Stem cell therapy has shown potential benefit in a variety of human diseases. However, there are limitations to the widespread clinical application including the use of invasive procedures to isolate cells and the need for processing. Adipose-derived stromal/stem cells (ASC) are adult cells that possess the capacity for homing, immunomodulation, promotion of repair, and direct regeneration of damaged tissues, which make them promising therapeutic candidates. Furthermore, these cells can be easily obtained in large quantities from subcutaneous tissue, allowing for an abundance of cells to be isolated relatively easily.
This study demonstrates that therapeutic cells from frozen umbilical cord units can be expanded ex vivo and retain their therapeutic properties. The cells were used to treat diabetic skin ulcers and demonstrated faster wound closure and improved skin regeneration compared to controls.
Combined treatment of spinal cord injury with adipose-derived stem cells and olfactory ensheathing cells leads to high levels of repair in a rat model