Featured Articles

Skin‐Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration

Corneal endothelial dysfunction is a common cause of corneal blindness. Our work describes how functional corneal endothelial cells can be derived from neural crest cells isolated from facial skin (SKPs) of mice and humans. SKPs can be isolated from surgically removed redundant skin, suggesting that they can be used as an autologous source for regenerating the cornea.



New Monoclonal Antibodies to Defined Cell Surface Proteins on Human Pluripotent Stem Cells

This manuscript describes the production and characterization of seven new monoclonal antibodies. These antibodies are significant because they enable new explorations of human pluripotent stem cells. The antibodies should be useful for gaining a better understanding of human pluripotency, enriching for human pluripotent stem cells, removing pluripotent stem cells, and also for performing similar functions with subsets of human breast and colon tissue.

 

Journal Club Discussions

February 12, 2017

New research suggests that changes to the metabolic profile of aggregated hMSCs enhance stem cell characteristics

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Article Scans

February 19, 2017
Researchers discover that a combination MSC treatment inhibits retinal degeneration and vision loss in a mouse model
February 19, 2017
A new study demonstrates that the combination of iPSCs and gene correction technology may provide a patient-specific means to treat inherited blood disorders
February 19, 2017
Researchers identify and characterize different neural stem cell populations derived from the spinal cord and describe how injury and MBP control their activity

Video Summary

Video abstract from Dr. Hochane et al. on his recently published STEM CELLS paper entitled, "Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC." Read the paper here.

Video abstract from Dr. Dunaway et al. on his recently published STEM CELLS paper entitled, "Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns." Read the paper here.

Video abstract from Drs. Barnawi, Al-Khaldi, Sleiman, Sarkar, Al-Dhfyan, Al-Mohanna, Ghebeh, and Al-Alwan on their recently published STEM CELLS paper entitled, "Fascin is Critical for the Maintenance of Breast Cancer Stem Cell Pool Predominantly via the Activation of the Notch Self-Renewal Pathway" Read the Paper here.

Graphical Abstracts

Confocal picture showing the myelinogenic potential of hiPS-NSCs engrafted at the border between the striatum and the corpus callosum of immunodeficient MLD mice at 3 months post-transplantation(green, human cells labeled with anti-human mitochondria; red, myelin basic protein; blue, nuclei counterstained with ToPro3). Scale bar: 100µm.

An ex vivo culture system used to isolate scalable quantities of hS/PCs with consistent expression of progenitor markers, is reported here. These hS/PCs can be maintained in long-term culture in 2D or in 3D, without loss of stem/progenitor markers.  Incorporation of bioactive basement membrane-derived peptides in the 3D hyaluronate (HA) hydrogel culture system enhances progenitor expansion.  Stimulation of hS/PC spheroids with neurotransmitter agonists leads to differentiation toward an acinar lineage.

Stem cells are emerging as a scientifically plausible treatment and possible cure for cerebral palsy, but are not yet proven. The lack of valid animal models has significantly hampered the scope of clinical trials. Despite the state of current treatment evidence, parents remain optimistic about the potential improvements from stem cell intervention and feel compelled to exhaust all therapeutic options, including stem cell tourism. Receiving unproven therapies from unvalidated sources is potentially dangerous. Thus it is essential that researchers and clinicians stay up to date. A systematic review and meta-analysis summarizing and aggregating current research data may provide more conclusive evidence to inform treatment decision making and help direct future research.