In this article researchers report long-term results of five patients who received a cranioplasty using autologous adipose-derived stem cells seeded on beta-tricalcium phosphate granules. The initial results were promising, with no serious complications. Nevertheless, the 6-year follow-up results of the five cases are unsatisfactory. The use of this strategy for cranial defect reconstruction must be studied further before continuing with clinical trials and before applying the method in clinical practice.
Muscle dystrophies (MDs) are pathologies characterized by chronic degeneration of muscles. This induces a sustained and continuous regeneration that depends on satellite cells (SCs). Defective regeneration and SC pool exhaustion ultimately lead to the replacement of muscles with scar tissue and loss of functionality. Unacylated ghrelin (UnAG) is a circulating hormone with protective activities on skeletal muscles. Here we demonstrated that UnAG helps to maintain the pool of SCs and that it has a beneficial effect on muscles of dystrophic mice. UnAG could represent a novel treatment for MDs, either alone or as an adjuvant therapy for one of the promising stem cell-based therapies.
New studies in mice suggest that stem Leydig cell transplantation may represent an effective means to treat testosterone efficiency in humans