Featured Articles

Concise Review: Fabrication, Customization, and Application of Cell Mimicking Microparticles in Stem Cell Science

The article discusses the various fabrication and customization methodologies capable of producing cell mimicking microparticles (CMMPs), as well as which of these techniques is optimal for particular applications or compatible with specific materials. The Concise Review describes current and potential applications in tissue engineering/regenerative medicine, drug delivery, diagnostic tools, and more. Also included are expected timelines as to when such applications are likely to be adopted and suggestions on where future development of this technology should be focused for producing more accurate cell mimics. The readers should be able to easily identify the pros and cons of the various fabrication procedures as they relate to different applications, as well as how the customization methods can enhance CMMP-based experiments or therapies.



Concise Review: Cell Therapy for Critical Limb Ischemia: An Integrated Review of Preclinical and Clinical Studies

It remains a challenging era for the clinical development of improved cell therapy strategies for critical limb ischemia (CLI). For the first time, we have the capacity to generate the cells to model complete vessel formation from exogenous allocgeneic and or autologous sources using combinatorial delivery of vessel-forming endothelial precursor cells, with pro-angiogenic hematopoietic progenitor cell, and vessel-stabilizing mesenchymal stem cell, within implantable decellularized matricies in vivo. Unfortunately, the morbidity and mortality from CLI remains unacceptably high and the need for well-controlled translational studies in this area cannot be overemphasized. Thus, careful preclinical evaluation of emerging concepts and technologies are critical for the expedited development of cell therapy trials for CLI.

 

Journal Club Discussions

January 6, 2018

New research demonstrates how proinflammatory stimuli can promote the production of extracellular vesicles from MSCs with enhanced immunomodulatory capacity.

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Article Scans

January 15, 2018
A new study suggests that PPARα-laden membrane microparticles can reverse loss function of endothelial progenitor cells in a mouse model of metabolic syndrome
January 15, 2018
The efficient production of specialized endothelial cells from pluripotent stem cells may accelerate the construction of a reliable blood-brain barrier model 
January 6, 2018
Researchers describe a robust and simple means to assess quality control in cultures of human embryonic stem cell cultures: intact cell mass spectrometry fingerprinting