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Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine

There is a pressing need for more wide-ranging characterization metrics for mesenchymal stem cells (MSCs) that better and more accurately predict treatment outcomes of MSC-based therapies. This Review provides a detailed account of what are currently thought to be defining characteristics of MSCs and further considers recent advances that may prove to be important criteria when considering clinical applications. The relationship between in vitro characteristics and in vivo potency, and strategies to improve the efficacy of MSC therapy is also addressed.



Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet‐Derived Growth Factor on Human Retinal Ganglion Cells

Stem cell therapies that work in rodent models are frequently proposed as potential treatments for human disease. Testing of such strategies in human tissue is an important interim between preclinical and clinical studies. This study demonstrated that human mesenchymal stem cells and platelet-derived growth factor provide significant protection to cells of the human retina, supporting observations seen in rodent models of optic nerve injury. This work highlights that similar, although not identical, mechanisms are responsible for retinal protection and that future stem cell-based treatments may have the potential to reduce visual deterioration.

 

Journal Club Discussions

October 30, 2017

By combining solubilized amniotic membrane into an easy to store and apply hydrogel, researchers have developed a cell-free means to accelerate wound healing

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Article Scans

November 12, 2017
A new study employs patient samples to develop a new induced pluripotent stem cell model of the dry form of age-related macular degeneration, a common cause of blindness
November 12, 2017
A new study employs CRISPR/Cas9 gene-editing to uncover differing developmental roles for the OCT4 pluripotency gene in human and mouse early embryos
November 6, 2017
Researchers have improved the differentiation of RGCs by creating a new and improved reporter human ESC line generated via CRISPR/Cas9 genome editing